The Glacial® Skin Story

Headquartered in Silicon Valley, R2 Technologies is the world leader in CryoAesthetics™ medical devices. Our Glacial® platform for precision contact cooling of the skin has been shown to reduce inflammation and also brighten dark spots.

In 2014, Pansend Life Sciences, LLC, the life sciences segment of INNOVATE (NYSE: VATE), founded R2 together with Blossom Innovations, LLC and Massachusetts General Hospital to develop a technology based on their patented method of CryomodulationTM. In 2019, R2 brought on a strategic partner, Huadong Medicine Co., Ltd.

Since that time, R2 has conducted the design, development and extensive clinical research to bring Glacial® Rx, Glacial® fx and Glacial® Spa to market along with an exciting product pipeline.


Our scientific founders and world-famous luminaries in aesthetic medicine, focus on the development, engineering, clinical research, and commercialization of groundbreaking technologies for aesthetic providers and consumers.

R. Rox Anderson, M.D., GlacialRx
R. Rox Anderson, M.D.
Dieter Manstein, M.D., PhD, GlacialRx
Dieter Manstein, M.D., PhD
Henry H. L. Chan, M.D., PhD, GlacialRx
Henry H. L. Chan, M.D., PhD


Our experienced leadership team is passionate about bringing Glacial® Skin to clinics and spas worldwide so everyone can experience the benefits of healthy Glacial skin.

Tim Holt President and CEO of GlacialRx, R2 Technologies
Tim Holt
President & CEO
Tim has over 20 years of experience leading, launching, and scaling aesthetic medical device companies, including Reliant, ZELTIQ, Fraxel, and CoolSculpting.
Kristine Tatsutani Chief Science & Technology Officer
Kristine Tatsutani
Chief Science & Technology Officer
Kristine has over 25-years in cryobiology research, developing cold-based medical devices, and serving as leadership for ZELTIQ.
Joanne Kells National Sales Director for GlacialRx
Joanne Kells
VP of Sales & Marketing
Joanne has over 17 years experience in the medical aesthetic industry, driving top sales and leading high- performing teams at Allergan, Merz, and Solta.
Angell Haiflich VP of Finance & Administration
Angell Haiflich
VP of Finance & Administration
Angell has over 20 years of experience in finance and accounting across multiple industries, including performing audits for Fortune 500 companies.
Casey Torrez VP of Operations
Casey Torrez
VP of Operations
For over 20 years, Casey has led high-performing teams in sales operations, customer service, and logistics in medical aesthetics and lifesciences.
Amy Harrington
VP of Clinical Education & Practice Development
Amy Harrington, RN is a clinical leader providing clinical training, sales education and practice development.
James Hastings
James Hastings
Executive Director of Product and Program Management
James has over 20 years of experience driving marketing, sales and distribution management at well-known startups.

Board of Directors

David A. Present, MD
Chairman, Founder, and General Partner, Pansend Life Sciences, LLC
Cherine Eldumiati Plumaker
Vice Chairman, Founder, and General Partner, Pansend Life Sciences, LLC
Irina Erenburg, PhD
Founder and Chief Executive Officer, Blossom Innovations, LLC
Yuhang Zhao, PhD, MBA
Adviser to China Grand, Inc.
Seth Orlow, MD, PhD
Professor and Chair of Dermatology, NYU School of Medicine
Tim Holt, MBA
President and Chief Executive Officer, R2 Technologies, Inc.
Elaine Zhou
CEO of Sinclair China
Ken Cappell
Retired Partner PricewaterhouseCoopers LLP

Exclusive Partners

Allies of Skin

Founded in 2016 by Nicolas Travis, a Forbes “30 Under 30,” and sold in more than 29 markets worldwide and counting, cult-favorite brand Allies of Skin creates multi-benefit formulas for all skin types that work harder and smarter.

Huadong Medicine Company, Limited

Huadong Medicine Co., Ltd., is a leading Chinese pharmaceutical company based in Hangzhou, China. Huadong Medicine possesses one of the most extensive commercial coverage and marketing capabilities in China.

Fraxel is a registered trademark of Solta and CoolSculpting is a registered trademark of Allergan.

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